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KMID : 0613820190290040455
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Journal of Life Science
2019 Volume.29 No. 4 p.455 ~ p.460
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The Effect of Fermented Extracts of Korean Dendropanax Morbifera Leveille on Hair Growth
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Park Tae-Hee
Park Se-Ho
Lee Jae-Yeul
Yang Seun-Ah
Jhee Kwang-Hwan
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Abstract
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In previous studies, we confirmed the effective antimicrobial activity of fermented Dendropanax morbifera leaf/branch extracts with Lactobacillus plantarum ilchiwhangchil 1785 and Lactobacillus plantarum ilchiwhangchil 2020. In this study, we investigated the hair growth effect of D. morbifera leaf/branch extracts fermented with L. plantarum ilchiwhangchil 1785 and L. plantarum ilchiwhangchil 2020 on human hair dermal papilla cells. The growth rate of human hair dermal papilla cells treated with fermented extracts in the range of 1 to 10 μg/ml significantly increased in a concentration-dependent manner, without increasing cell death. Double staining studies showed that the growth of cells treated with fermented D. morbifera leaf/branch extracts was more active than that of control cells. Moreover, the cells treated with the fermented D. morbifera leaf/branch extracts exhibited a 18.84% and 23.31% increase in cell mobility, respectively, as compared with that of the untreated cells. High-performance liquid chromatography (HPLC) was used to determine the active agents responsible for hair growth. The results showed that the content of β-sitosterol, which is known to affect hair growth, increased about 10 times in the fermentation process of D. morbifera leaf/branch extracts. Taken together, the findings confirm that fermented Dendropanax morbifera leaf/branch extracts promote hair growth.
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KEYWORD
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Dendropanax morbifera, hair growth, Lactobacillus plantarum ilchiwhangchil 1785, Lactobacillus plantarum ilchiwhangchil 2020, β-sitosterol
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